Androgen receptor(AR),a ligand-activated transcription factor,is a master regulator in the development and progress of p......

Adhesion of leukemia cells to stromal cells confers resistance tospontaneous and drug-induced cell death of leukemia cel......

Many leukemia cells highly express chemokine receptor of CXCR4 that actively responses to CXCL12 constitutively secreted......

The metastasis of breast cancer is mainly regulated by chemokine receptors such as CXCR4.As reported,neutralizing the in......

Objective Our previous studies have demonstrated that neuropeptide S(NPS),via selective activation of the neurons bearin......

Objective When food is available during a restricted and predictable time of the day, mammals exhibit food-anticipatory ......

Cysteinyl leukotrienes (CysLTs) induce inflammatory responses by activating their receptors,CysLT1R and CysLT2R.We have ......

Hypoxia-inducible factor-2(HIF-2)is a heterodimeric transcription factor formed through the dimerization of an oxygensen......

The pregnane X receptor (PXR,NR1I2),a member of the nuclear receptor (NR) superfamily,is activated by a number of clinic......

Objective: To determine whether the neurotoxin rotenone induces expression and release ofmicroglial proinflammatory cyto......

Aim: αvβ3 integrin has been reported as a promising therapeutic target for angiogenesis.Numerous αvβ3 antagonists ha......

Objective: To study the effects of β 3-adrenoceptor (β3-AR) activation on lipid, glucose metabolism and atheroscleroti......

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Toll-like receptors(TLRs)are highly conserved transmembrane proteins which detect pathogen-associated molecular patterns......

Microfluidics and micrometer-scale total analysis systems (μTAS) have been experienced a fast development in last two d......

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A wide variety of genetic and non-genetic pathologies share serious psychiatric symptoms, which determine a poor quality......

　　Prostate cancer(PCa),an epithelial malignancy that occurs in the prostate,reminds the second leading cause of cancer......

Objective To analyze the clinical features and outcome of patients who used different pretreatments before application o......

<正> Lioresal [β-(4-chlorophenyl)-γ-aminobutyric acid] is a GABA-derivative, which not only inhibits the spinal monosy......

<正> The opiate antagonist naloxone could partially reverse acupuncture analgesia. This has provided an indirect support......

AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100......

A novel and efficient method was developed for the synthesis of diarylpyrazole derivatives as cannabinoid CB1 receptor a......

A novel and practical synthetic route is presented for the preparation of methyl-(E)-2-(3-(3-(2-(7-chloro-2-quinolinyl)e......

A facile synthesis of suvorexant,an orexin receptor antagonist,is described.The key intermediate 6 was prepared from R-3......

AIM: To explore the feasibility of human growth hormone (hGH) receptor antagonist in the treatment of end-stage diabeti......

We have previously found that several families of nonpolar short chain 11 β-ethers and esters of estradiol are selectiv......

This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on a......

AIM: To study the efficacy of marrow mesenchymal stem cells (MSCs) transplantation combined with interleukin-1 receptor ......

Aim:To investigate the mechanisms of interleukin-1 receptor antagonist (IL-1ra)in the treatment of adjuvant arthritis (......

A series of benzoxepin-5-ones were designed and synthesized by the cyclization of chalcones which were previously found ......

To determine which subtype of α1-adrenergic receptors plays a role in the regulation of blood pressure, with α1A-adre......

Objectives To investigate the effects ofβ2-adrenergic antagonist on cytosolic Ca2 + ([Ca2+]i) in ventricular myocytes f......

Aim:The downregutation of phospholamban (PLB) and FKBP12.6 as a result of β-receptor activation is involved in the pat......

AIM: To characterize the antinociceptive action of the novel melatonin receptor(MT) agonists, Neu-P11 and Neu-P12 in ani......

Objectives To study the effects of bradykinin (BK) B2 receptor blockade on infarct size and hemodynamics after myocardia......

术语ｂｌｏｃｋｅｒ、ａｎｔａｇｏｎｉｓｔ和ｉｎｈｉｂｉｔｏｒ有区别吗？在生物医学期刊、专著和教材中，常见混用ｂｌｏｃｋｅｒ、ａｎｔａｇｏｎｉｓｔ和ｉｎｈｉｂｉｔｏｒ的情况。尽管三者在表达生理功能或药理作用的水平上相当近似，但严格区......

Ohmefentanyl has significant inhibitory actions on the electrically evoked contractions of guinea pigileum and mouse va......

The title compound is one of the scries of Ca-antagonist. We study its structure and properties to develope the efficie......

AIM:Carvedilol,a third-generation,nonselectiveβ-adrenoreceptor antagonist,possesses both reactive oxygen species(ROS)sc......

Feng Fengyi , Zhang Pin , He Youjian 1, Li Yuhong1 , Zhou Meizhen2 , Chen Gang2 and Li Lin2 The Cancer Hospital of the......

A series of 1-(N-(2-(2-methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols derivatives were designed and synth......

Valsartan 1,one of the most important agents used in antihypertensive therapy today,was synthesized starting from L-vali......

A 57-year-old woman was referred to our hospital becauseof a liver mass detected by computed tomography.She hadtaken or......

Aim:To explore the effect of androgen receptor (AR) on the expression of the cell cycle-related genes,such asCDKN1A and......

In order to compare GnRH agonist with antagonist protocol for the same patient during controlled ovarian stimulation cyc......

Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain, improve brain e......

AIM: To investigate the effects of AT1 (Type 1 angiotensin Ⅱ receptor) antagonist (Losartan) on the apoptosis,prolifera......